The Science
AETHERA's interpretive framework draws on five converging fields. Each discipline contributes a layer of signal that, in isolation, would be partial — and together describe a body that is constantly adapting.
I
We model the body as an interdependent network of feedback loops rather than a stack of isolated organs. Every signal is interpreted in the context of the system it emerged from.
Anchors
· Kitano, H. (2002) Systems Biology
· Hood, L. (2013) P4 Medicine
II
How environment, behaviour and time express through the genome. We pay particular attention to methylation drift, chronic inflammatory tone, and the chrono-biology of gene expression.
Anchors
· Horvath, S. (2013)
· Lu, A.T. (2019) GrimAge
III
Sleep architecture, heart-rate variability, and the regenerative rhythms of repair. The most under-utilised lever in modern longevity is consistent, high-quality recovery.
Anchors
· Walker, M. (2017)
· Plews, D. (2013) HRV-guided training
IV
Autonomic regulation, attention, and the neurochemistry of clarity. Cognitive performance is downstream of nervous-system load — we treat it that way.
Anchors
· Porges, S. (2011) Polyvagal Theory
· Sapolsky, R. (2004)
V
The capacity of biology to widen — or narrow — under load. Adaptability is the master variable of longevity. We score it directly.
Anchors
· Schulkin, J. Allostasis
· Friston, K. (2010) Free-energy